Filter:
| Protein family | Description | Reference |
|---|---|---|
| ABA3 | ABA3 is a noncanonical sesquiterpene synthase involved in the biosynthesis of abscisic acid in fungi. |  |
| ACP_PCP | Acyl carrier protein (ACP) or peptidyl carrier protein (PCP) domains found in fungal polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs). | |
| AnkA | AnkA is an arginine-containing cyclodipeptide synthase (RCDPS) that shows no sequence similarity with nonribosomal peptide synthases. Its homologues have been identified in many fungal species. | |
| AnkG | AnkG is an ATP-grasp enzyme for NK13650 C biosynthesis. | |
| AsR5 | AsR5 is a hetero Diels–Alderase involved in the biosynthesis of xenovulene A. | |
| AsR6 | AsR6 is a noncanonical sesquiterpene synthase involved in the biosynthesis of xenovulene A and cyclizes farnesyl pyrophosphate (FPP) into humulene. | |
| AstC | AstC is a noncanonical class II sesquiterpene synthase responsible for astellolide biosynthesis and forms drimanyl pyrophosphate. | |
| ATEG_03636 | ATEG_03636 is involved in the biosynthesis of azasperpyranone A and is proposed to be responsible for the heterodimerization of preasperpyranone and a polyketide-derived aromatic aldehyde. | |
| AtnE | AtnE is a transcription factor for arthripenoid biosynthesis. | |
| BfL6 | BfL6 is a ketosteroid isomerase-like protein, which is involved in the hybridization of butenyl carboxymethyl maleic anhydride and its decarboxylated form to yield byssochlamic acid. | |
| BfL8 | BfL8 is a putative regulatory protein for byssochlamic acid biosynthesis. | |
| CalD | CalD is an acyltransferase involved in the biosynthesis of calbistrin A and performs esterification of the decalin and polyene portions. | |
| CghF | CghF is a transcription factor for Sch 210972 biosynthesis. | |
| Clz3 | Clz3 is a copper-dependent oxygenase involved in the biosynthesis of zaragozic acid A. The enzyme is homologous to MfM1 responsible for squalestatin biosynthesis. | |
| Clz7 | Clz7 is a transcription factor for zaragozic acid A biosynthesis. |
|
| CosA | CosA is an unusual UbiA-like prenyltransferase for cosmosporaside biosynthesis. | |
| Cp1D | Cp1D is an amide bond synthetase for CPI-2 biosynthesis. | |
| CpaE | CpaE is a transcription factor for curvupallide biosynthesis. | |
| CtvD | CtvD is an epoxide hydrolase involved in the biosynthesis of citreoviridin. Its homologues with an unknown function (e.g., PaxA) are often encoded by indole diterpenoid biosynthetic gene clusters. | |
| EcdJ | EcdJ is a hypothetical protein encoded by the echinocandin B biosynthetic gene cluster. | |
| EfHP | EfHP1, EfHP2, and EfHP3 are all hypothetical proteins encoded by the elsinochrome biosynthetic gene cluster. | |
| ElcH | ElcH is a berberine bridge enzyme-like oxidase involved in the biosynthesis of elsinochrome A and responsible for the coupling of two naphthol derivatives in collaboration with another enzyme ElcG. | |
| EqxR | EqxR is a transcription factor for equisetin biosynthesis. | |
| FncF | FncF is a short-chain dehydrogenase/reductase involved in the biosynthesis of funiculolide D and serves as an enoylreductase. | |
| fPKS_DH | Dehydratase (DH) domain found in fungal polyketide synthases (PKSs). DH domains are observed in highly reducing (HR)-PKSs. | |
| fPKS_ER | Enoylreductase (ER) domain found in fungal polyketide synthases (PKSs). | |
| fPKS_KR | Ketoreductase (KR) domain found in fungal polyketide synthases (PKSs). | |
| fPKS_PT | Product template (PT) domain found in fungal polyketide synthases (PKSs). PT domains are observed in non-reducing reducing (NR)-PKSs and show sequence similarity with DH domains. | |
| fPKS_R | Reductase (R) domain found in fungal polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs). This protein family includes Dieckmann condensation (DKC) domains found at the C-terminus of fungal PKS-NRPS hybrid enzymes. | |
| fPKS_TH | Thiohydrolase (TH) domain found in fungal polyketide synthases (PKSs). TH domains are observed in partially reducing (PR)-PKSs and show sequence similarity with DH domains. | |
| FPSE_09189 | FPSE_09189 is a putative transcription factor for W493 B biosynthesis. | |
| FrzJ | FrzJ is a phosphotransferase involved in the biosynthesis of FR901483. | |
| Fsa2 | Fsa2 is a Diels-Alderase involved in the biosynthesis of fusarisetin A and forms the decalin ring system. | |
| FscB | FscB is a transcription factor for fusarochromene biosynthesis. | |
| GGPS | This protein family mainly includes geranylgeranyl pyrophosphate (GGPP) synthase (GGPS) but also contains other polyprenyl pyrophosphate synthases. | |
| GliK | GliK is a γ-glutamyl cyclotransferase-like enzyme that removes the γ-glutamyl moieties in gliotoxin biosynthesis. | |
| GliN | GliN is an N-methyltransferase involved in the biosynthesis of gliotoxin. | |
| GsfR1 | GsfR1 is a transcription factor for griseofulvin biosynthesis. | |
| HimD | HimD is a transcription factor for himeic acid A biosynthesis. | |
| LcsT | LcsT is a short-chain dehydrogenase/reductase encoded by the leucinostatin A biosynthetic gene cluster. | |
| LolU | LolU is a transcription factor for N-formylloline biosynthesis. | |
| LtmS | LtmS is a hypothetical protein encoded by the lolitrem B biosynthetic gene cluster. | |
| MdpA | MdpA is a transcriptional coactivator for shamixanthone biosynthesis. | |
| NRPS_C | Condensation (C) domain found in fungal nonribosomal peptide synthetases (NRPSs). | |
| NRPS_E | Epimerization (E) domain found in fungal nonribosomal peptide synthetases (NRPSs). E domains show sequence similarity with C domains. | |
| NRPS_CT | Terminal condensation domain (CT) domain found in fungal nonribosomal peptide synthetases (NRPSs). CT domains are often found at the C-terminus of fungal NRPSs and are responsible for peptide chain release by macrocyclization, hydrolysis, or further incorporation of an amino acid. | |
| NvfI | NvfI is an Fe(II)/α-ketoglutarate-dependent dioxygenase that performs endoperoxidation in the biosynthesis of novofumigatonin. | |
| OphC | OphC is a hypothetical protein encoded by the omphalotin biosynthetic gene cluster. | |
| OtaR1 | OtaR1 is a transcription factor for ochratoxin A biosynthesis. | |
| PatF | PatF is one of the biosynthetic enzymes of patulin and converts phyllostine to neopatulin. | |
| PatJ | PatJ is a cupin domain-containing protein involved in the biosynthesis of patulin and is predicted to be responsible for the transformation of gentisaldehyde to isoepoxydon. | |
| PaxC | PaxC is an isoprenyl pyrophosphate synthase (IPPS)-like geranylgeranyltransferase involved in the biosynthesis of paxilline. PaxC accepts glyceraldehyde 3-phosphate and geranylgeranyl pyrophosphate as substrates to yield 3-geranylgeranyl indole (GGI). | |
| PbcA | PbcA is a bifunctional diterpene synthase that performs both class I and class II cyclizations to yield ent-pimara-8(14),15-diene. | |
| PenF | PenF performs cationic epoxide rearrangement in the biosynthesis of penigequinolone. | |
| PfB | PfB is a pericyclase involved in the biosynthesis of (–)-PF1018. | |
| PhomB | PhomB is a hypothetical protein encoded by the phomopsin A biosynthetic gene cluster. | |
| PKS_NRPS_MT | Methyltransferase (MT) domain found in fungal polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs). | |
| PydY | PydY is a hypothetical protein encoded by the pyrrocidine biosynthetic gene cluster and is proposed to catalyze the Diels-Alder reaction. | |
| Pyr4 | Pyr4 is a noncanonical transmembrane terpene cyclase involved in the biosynthesis of pyripyropene A. Its homologues are responsible for the production of diverse microbial meroterpenoids, including polyketide-terpenoid hybrids and indole diterpenoids. | |
| SalTPS | SalTPS is a noncanonical terpene synthase from Streptomyces alanosinicus. Its homologues have been found in fungi, although their functions have yet to be experimentally investigated. | |
| SAT2 | Starter-unit acyltransferase (SAT) domain found in fungal nonreducing polyketide synthases (NR-PKSs). | |
| SdnJ | SdnJ is a glycosyltransferase involved in the biosynthesis of hypoxysordarin. | |
| SmbD | SmbD is a short-chain dehydrogenase/reductase involved in the biosynthesis of (-)-sambutoxin and is proposed to serve as a ketoreductase. | |
| Spd14 | Spd14 is a transporter for sporidesmin biosynthesis. | |
| SrdD | SrdD is a cupin domain-containing protein involved in the biosynthesis of sordarial. Some members of this protein family are predicted to serve as a polyketide cyclase (aromatase) in fungal alkyl salicylaldehyde biosynthesis. | |
| TdiC | TdiC is a medium-chain dehydrogenase/reductase involved in the biosynthesis of terrequinone A. | |
| TqaK | TqaK is a transcription factor for tryptoquialanine biosynthesis. | |
| Tri6 | Tri6 is a transcription factor for trichothecene biosynthesis. | |
| Tri14 | Tri14 is a hypothetical protein encoded by the trichothecene biosynthetic gene cluster. | |
| Trt5 | Trt5 is a methyltransferase involved in the biosynthesis of terretonin and methylates the carboxy group of farnesyl-DMOA. | |
| Trt14 | Trt14 is an isomerase involved in the biosynthesis of terretonin and achieves ring expansion reaction in collaboration with another enzyme Trt6. | |
| TwmC | TwmC is a G protein-coupled receptor (GPCR)-like protein encoded by the wortmanamide biosynthetic gene cluster. | |
| UbiA_PT | This protein family includes UbiA-like prenyltransferases that are involved in the biosynthesis of diverse fungal meroterpenoids. | |
| UbiA_TC | This protein family includes UbiA-like terpene cyclases, as represented by Fma-TC responsible for fumagillin biosynthesis. | |
| VicY | The biosynthetic gene clusters of victorins encode several VicY proteins. This protein family includes VicY proteins that contain two “HXXHC” motifs, which are characteristic of the DUF3328 domain-containing proteins, although the DUF3328 domain is not found in these proteins. | |
| VidS | VidS is a dehydratase involved in the biosynthesis of demethoxyviridin and performs dehydration reaction to form the furan ring system. | |
| VrtF | VrtF is an O-methyltransferase involved in the biosynthesis of viridicatumtoxin. | |
| XenC | XenC is involved in the biosynthesis of xenoacremone A and is proposed to catalyze the paracyclophane ether formation. | |
| XenD | XenD is proposed to serve as hydroxylase/epoxidase in the biosynthesis of xenoacremone A. | |